Influenza can be associated with various neurologic and behavioral symptoms (including hallucinations, delirium, abnormal behavior), with fatal outcomes in some cases; such events may occur with encephalitis or encephalopathy but can occur without obvious severe disease. There are postmarketing reports (mostly in Japan) of delirium and abnormal behavior leading to injury, with fatal outcomes in some cases, in influenza patients using this drug. Although frequency is unknown, based on usage, these events appear uncommon. These events were primarily reported in pediatric patients, often with abrupt onset and rapid resolution. The contribution of this drug to such events has not been established.
Side effects with similar or higher incidence among placebo patients included insomnia. [ Ref ]
One of the follow-up solutions to a cystectomy is the creation of a neobladder (one form of which is named Studer's Ileal Neobladder or the Studer Pouch). A neobladder is a loop of intestine that is surgically fashioned into a pouch and placed in the location of the original bladder. It is then attached to the ureters and the urethra , thus simulating the function of the original organ. The kidneys filter the urine into the neobladder which can often be emptied by muscle control. There are side effects of this complex surgery, including partial shut down of the digestive system (in response to removal of the piece of intestine), incontinence , and the loss of the nerves that signal a full bladder.
As a demon, Dean's soul became twisted and he no longer empathized with others. He cared only for himself and what he needed. His change was so drastic that he stalked Sam throughout the Bunker with the intent of killing him using a hammer, only to miss by a few inches. He carried out this task calmly, and coupled it with taunts, giving the impression that he was enjoying himself. This is furthered by the fact that instead of an axe, he decides to use a hammer to break through a door and kill Sam, despite both tasks requiring much more force with a hammer than with an axe. Demon!Dean apparently cared about the natural order , something old Dean despised. He even considered himself, as a demon, a part of the natural order, and that it was all set up in this certain way.