Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.
Weider had enjoyed some success as a bodybuilder but far less as a weightlifter, and vehemently disagreed with the AAU rules that Hoffman had helped draft. Requiring that a bodybuilder shoulder-press 200 pounds, for instance—something that Weider struggled and, at times, failed to do—made little sense in the context of what was essentially an aesthetic contest. Moreover, Weider argued that Hoffman was unfairly overlooking African American athletes with impressive physiques, citing Melvin Wells’s failure to claim the Mr. America crown on several prior occasions. During the late 1950s and early 1960s, Weider would attempt to remedy these oversights by using his publications to promote the careers of black bodybuilders such as Rick Wayne, Harold Poole, and Chris Dickerson. But for Weider, racial equality came second to aesthetics: He was willing to consider anyone as a possible champion, so long as they had the look he prized.