Steroid nasal spray brands in pakistan

Azelastine hydrochloride displayed no sensitising potential in the guinea pig. Azelastine demonstrated no genotoxic potential in a battery of in vitro and in vivo tests, nor any carcinogenic potential in rats or mice. In male and female rats, azelastine at oral doses greater than 3 mg/kg/day caused a dose-related decrease in the fertility index; no substance-related alterations were found in the reproductive organs of males or females during chronic toxicity studies, however, embryotoxic and teratogenic effects in rats, mice and rabbits occurred only at maternal toxic doses (for example, skeletal malformations were observed in rats and mice at doses of mg/kg/day).

Side effects/ Undesired effects/ Adverse drug reactions: Systemic steroid effects on higher doses. - / / / This entry was posted in Asthma Medications . Bookmark the permalink . ← Beclate-N Cream Beclo Lotion → 2 Responses to Beclate Nasal Spray / Beclate Aquanase Nasal Spray

  1. Elaine Simpson says: October 25, 2011 at 7:04 am I have been using Beclate for more than a year. Lately I have been feeling very cloggy in the nose. I have found that if I miss a day it feels better, but if I go longer, my phlegmmy symptoms come back.
    I know I must keep on using, or my symptoms will be back, but it is also very uncomfortable at nigh when I can’t breathe through my nose. Is this caused from the long use of Beclate or is it something else? Please could you advise me.
    Elaine

    The precise mechanism through which fluticasone propionate affects rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. In 7 trials in adults, fluticasone propionate nasal spray has decreased nasal mucosal eosinophils in 66% of patients (35% for placebo) and basophils in 39% of patients (28% for placebo). The direct relationship of these findings to long-term symptom relief is not known.

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