Antioxidant compounds from Eucommia plant reduced the level of free radicals [ 66 , 67 ] and improved the disease condition caused by oxidative stress [ 68 , 69 ]. Strong antioxidant properties of EU have been established under in vivo and in vitro studies [ 70 , 71 ]. Extracts from EU reduced the level of hydrogen peroxide which expresses some caspase proteins by MC3T3E1 cells up to half concentration from to 25 μ g/mL [ 71 ]. Extract of EU was reported to increase the actions of erythrocyte, superoxide dismutase, and catalase and glutathione peroxidase and reduce the concentration of hydrogen peroxide and lipid peroxide in erythrocytes, liver, and kidney [ 70 ]. Studies on diabetic rats indicated that superoxide dismutase (SOD) can be enhanced by Eucommia bark. Eucommia also increases the level of other antioxidant enzymes in the blood to neutralize free radicals [ 70 ].