A study conducted by Chambers et al. in 2006 indicated that newborns whose mothers had started taking an SSRI such as Paxil after twenty weeks of becoming pregnant are six times more likely to develop PPHN than the general population. Another study by Källén et al. reported a significant relationship between the occurrence of PPHN and the use of antidepressant drugs such as Paxil during the first trimester of pregnancy. No association between the use of the SSRI drug during the third trimester of pregnancy and PPHN was found by the study conducted by Andrade et al. The FDA updated its safety warning in December 2011. As the review of more recent studies yielded additional findings that had to be taken into account, it was concluded that a final decision cannot yet be established about the relationship between the use of SSRIs and the development of PPHN.
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“Attention-deficit drugs increase concentration in the short term, which is why they work so well for college students cramming for exams. But when given to children over long periods of time, they neither improve school achievement nor reduce behavior problems. The drugs can also have serious side effects... Many parents who take their children off the drugs find that behavior worsens, which most likely confirms their belief that the drugs work. But the behavior worsens because the children's bodies have become adapted [because the drugs are habit-forming] to the drug. Adults may have similar reactions if they suddenly cut back on coffee, or stop smoking.”