Ostarine is one of the most popular and at the same time safe SARMs. Taking it in the indicated doses (10mg per day) doesn't block the hormone axis and, as far as we know, does not require an "unblock", however, it must be noted that every body is different. Beginners are recommend to start their dosage at 10mg per day. Experienced users are recommended to start with the same dose for the first week and then increased to 20mg, and if necessary even to 30 or 40 mg per day. Larger doses are pointless. Notable is the fact that the dose of 10mg a day is sufficient for therapeutic effect for the joints and can safely be used for up to 4-6 months without a break.