Before starting treatment, always inform your medical caregiver about any allergies or past and present medical history to allow him to make the correct choice. Never stop your treatment arbitrarily or alter the dose on your own. Your doctor should know if you are allergic to methylprednisolone acetate or any of the inactive ingredients in Depo-Medrol Injection. He should also know if you have Cushing's syndrome, tuberculosis, chickenpox, herpes simplex keratitis, systemic fungal infections or if you suffer from reactions to chicken pox vaccine. Before commencing your treatment with Depo-Medrol Injection, always inform your physician if you are pregnant, plan to become so or if you are nursing. Corticosteroids can make you susceptible to certain infections or mask their signs till such infections become serious. Using such formulations alone or concomitantly with other medications may make you vulnerable to infections from pathogens like bacterial, viral, fungal, protozoan or similar organisms. Your physician must therefore know if you are suffering from AIDS / HIV or diabetes before prescribing Depo-Medrol Injection. Always let your doctor know if you are suffering from sepsis syndrome, septic shock, seizure disorders, myasthenia gravis, any ocular infections, cardiac problems, hepatic ailments, renal impairments, osteoporosis, ulcerative colitis, or a family history of diabetes mellitus. Corticosteroid may cause adrenal insufficiency leading to muscle weakness, malaise, mental changes (like depression, mood swings, euphoria, personality changes etc.), muscle and joint pain, anorexia, dyspnoea, nausea and vomiting etc. Contact your physician immediately if you experience any such condition. Depo-Medrol Injection should be administered only through intramuscular, periarticular, intra-articular, intralesional and intrabursal route or into the tendon sheath. It should never be administered by the intravenous or intrathecal routes. Always use sterile disposable syringes to avoid contamination when using multiple doses of Depo-Medrol Injection from a single multi-dose vial. Take Depo-Medrol Injection with food in order to avoid stomach upset. Never share your medication with anybody else even if they show similar symptoms. Store the vial in a cool dark place away from children and pets. Never freeze vials and dispose off used vials properly.