The Poplar Bluff R-1 School District serves the educational needs of most of the residents of Poplar Bluff and the surrounding area. There are seven elementary schools, one junior high and one senior high school in the school district.  During the 2008–2009 school year, there were 4,934 students and 374 certified staff members enrolled in the Poplar Bluff R-1 School District. The school colors are maroon and white and its mascot is the mule. Athletics offered in the school district include boys' and girls' basketball, soccer, track, cross country, and tennis; boys' baseball, golf, football, and wrestling; and girls' softball, volleyball, cheerleading, and swimming.