NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
In 2014, it began its commercial operations in Colombia and the acquisition of the minority stake in Chile. Offices were also opened in Venezuela, Paraguay and Ecuador for the submission of dossiers. Thus, the organization started to cover % of the Latin American market. With an established presence with own operations in 20 countries in South and Central America, in the Caribbean and Africa. in 2014, the company completed the negotiation, becoming a shareholder in the North American Melinta Therapeutics and made commercial agreements with leading companies in South Korea (Don-A) and Sri Lanka (Ceyoka).